Issue information : Cell Death Differ. 2012 Apr;19(4):680-91.
Co-author : Kim JY, Kim DH, Kim JH, Lee D, Kim SM, Jeon HB, Kwon SJ, Choi SJ, Lee EH, Yoo YJ, Seo SW, Lee JI, Na DL, Yang YS, Oh W, Chang JW.
Link : https://www.ncbi.nlm.nih.gov/pubmed/22015609
This study demonstrates that in an Alzheimer’s type, amyloid-β developed in the hippocampus is reduced by human UCB derived MSCs. These data suggested that hUCB-MSC-derived sICAM-1 removes Aβ plaques indirectly by inducing NEP expression in microglia.
