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Stem Cells | 2022-04-18 HLA-A2 Promotes the Therapeutic Effect of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Hyperoxic Lung Injury
HLA-A2 in hUCB-MSCs is a major factor that enhances therapeutic effect in hyperoxic lung injury and inflammatory conditions.· Issue information | Bioengineering (Basel). 2022 Apr;9(4):177. doi: 10.3390/bioengineering9040177. · Co-author | Jihye Kwak, Wankyu Choi, Yunkyung Bae, Miyeon Kim, Soojin Choi, Wonil Oh, Hye Jin Jin |
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Stem Cells | 2022-02-01 CD26 Inhibition Potentiates the Therapeutic Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells by Delaying Cellular Senescence
CD26 is a potential novel target for the rejuvenation of senescent MSCs for their use in manufacturing MSC-based applications.· Issue information | Front Cell Dev Biol. 2021; 9: 803645. Published online 2022 Feb 1. doi: 10.3389/fcell.2021.803645 · Co-author | Miyeon Kim, Jinyoung Go, Ji Hye Kwon, Hye Jin Jin, Yun Kyung Bae, Eun-Young Kim, Eun-Ju Chang, Soo Jin Choi and Seong Who Kim |
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Stem Cells | 2021-09-14 Intracerebroventricular injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer’s disease dementia: a phase I clinical trial
Intracerebroventricular injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer’s disease dementia: a phase I clinical trial· Issue information | Alzheimers Res Ther. 2021; 13: 154. doi: 10.1186/s13195-021-00897-2 · Co-author | Hee Jin Kim, Kyung Rae Cho, Hyemin Jang, Na Kyung Lee, Young Hee Jung, Jun Pyo Kim, Jung Il Lee, Jong Wook Chang, Seongbeom Park, Sung Tae Kim, Seung Whan Moon, Sang Won Seo, Soo Jin Choi, and Duk L. Na |
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SMUP-Cell | 2021-09-14 PTX-3 Secreted by Intra-Articular-Injected SMUP-Cells Reduces Pain in an Osteoarthritis Rat Model
PTX-3 expression in injected SMUP-Cells, applied as a therapeutic strategy, reduced pain in an OA model.· Issue information | Cells. 2021 Sep 14;10(9):2420. doi: 10.3390/cells10092420. · Co-author | Minju Lee, Gee-Hye Kim, Miyeon Kim, Ji Min Seo, Yu Mi Kim, Mi Ra Seon, Soyoun Um, Soo Jin Choi, Wonil Oh, Bo Ram Song, Hye Jin Jin |
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PNEUMOSTEM | 2021-04-20 Stem cells for bronchopulmonary dysplasia in preterm infants: A randomized controlled phase II trial
In phase II clinical trial, intratracheal transplantation of PNEUMOSTEM might be safe and feasible, it did significantly improve the secondary outcome of severe BPD in preterm infants at 23 to 24 gestational weeks subgroup. Accordingly, we are now conducting an additional larger and controlled phase II clinical trial focusing on preterm infants at 23 to 24 gestational weeks.· Issue information | Stem Cells Transl Med. 2021 Aug;10(8):1129-1137. doi: 10.1002/sctm.20-0330. · Co-author | So Yoon Ahn, Yun Sil Chang, Myung Hee Lee, Se In Sung, Byong Sop Lee, Ki Soo Kim, Ai-Rhan Kim, Won Soon Park |
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Stem Cells | 2021-04-15 Positively correlated CD47 activation and autophagy in umbilical cord blood-derived mesenchymal stem cells during senescence
CD47 is a key player in autophagy and senescence to maintain and regulate the growth of MSCs, suggesting that CD47 may be a critical key marker for selection of effective stem cells in cell therapy.· Issue information | Stem Cells Int. 2021 Apr 15;2021:5582792. doi: 10.1155/2021/5582792. · Co-author | Gee-Hye Kim, Yun Kyung Bae, Ji Hye Kwon, Miyeon Kim, Soo Jin Choi, Wonil Oh, Soyoun Um and Hye Jin Jin |
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CARTISTEM | 2021-02-20 Allogenic Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Are More Effective Than Bone Marrow Aspiration Concentrate for Cartilage Regeneration After High Tibial Osteotomy in Medial Unicompartmental Osteoarthritis of Knee
CARTISTEM was more effective than BMAC augmentation for articular cartilage regeneration in Medial Unicompartmental Osteoarthritis of Knee.· Issue information | Arthroscopy. 2021 Aug;37(8):2521-2530. doi: 10.1016/j.arthro.2021.02.022. · Co-author | Nam-Hun Lee, Seung-Min Na, Hyeon-Wook Ahn, Joon-Kyoo Kang, Jong-Keun Seon, Eun-Kyoo Song |
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CARTISTEM | 2021-01-25 Allogenic umbilical cord blood-derived mesenchymal stromal cell implantation was superior to bone marrow aspirate concentrate augmentation for cartilage regeneration despite similar clinical outcomes
CARTISTEM was more effective than BMAC augmentation for articular cartilage regeneration in high tibial osteotomy (HTO) for medial compartmental knee osteoarthritis.· Issue information | Knee Surg Sports Traumatol Arthrosc. 2022 Jan;30(1):208-218. doi: 10.1007/s00167-021-06450-w. · Co-author | Hong‑Yeol Yang, Eun‑Kyoo Song, Sung‑Ju Kang, Woo‑Kyoung Kwak, Joon‑Kyoo Kang, Jong‑Keun Seon |
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Cord Blood | 2021-01-14 High Integrity and Fidelity of Long-Term Cryopreserved Umbilical Cord Blood for Transplantation
The high-viability recovery of long-term cryopreserved CB suggests that successful hematopoietic stem cell (HSC) transplantation and other clinical applications, which are suitable for treating incurable diseases, may be performed regardless of long-term storage.· Issue information | J Clin Med. 2021 Jan 14;10(2):293. doi: 10.3390/jcm10020293. · Co-author | Gee-Hye Kim, Jihye Kwak, Sung Hee Kim, Hee Jung Kim, Hye Kyung Hong, Hye Jin Jin, Soo Jin Choi, Wonil Oh, Soyoun Um |
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CARTISTEM | 2021-01-12 Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cell Implantation Versus Microfracture for Large, Full-Thickness Cartilage Defects in Older Patients: A Multicenter Randomized Clinical Trial and Extended 5-Year Clinical Follow-up
In the Phase 3 clinical trial, CARTISTEM implantation showed more durable improvement of pain and function up to 5 years compared with microfracture in patients with cartilage defects with or without osteoarthritis.· Issue information | Orthop J Sports Med. 2021 Jan 12;9(1):2325967120973052. doi: 10.1177/2325967120973052. · Co-author | Hong-Chul Lim, Yong-Beom Park, Chul-Won Ha, Brian J Cole, Beom-Koo Lee, Hwa-Jae Jeong, Myung-Ku Kim, Seong-Il Bin, Chong-Hyuk Choi, Choong Hyeok Choi, Jae-Doo Yoo, Cartistem Research Group; Jung-Ro Yoon, Jun-Young Chung |