Stem Cells | 2010-04-26
Application of human umbilical cord blood-derived mesenchymal stem cell in disease models.
This study explains that hUCB-MSC is a cell applicable to various diseases including cartilage injury, brain tumor, brain injury, pulmonary disease, and immune therapy as stem cell therapy.

· Issue information | World J Stem Cells. Apr 26, 2010; 2(2): 34. 38.
· Co-author | Kim JY, Jeon HB, Yang YS, Oh W, Chang JW.
Stem Cells | 2009-04-01
Down-regulation of CD105 is associated with multi-lineage differentiation in human umbilical cord blood-derived mesenchymal stem cells.
This study identified that by controlling expression of CD105 known as a cell surface antigen, this antigen is associated with differentiation of hUCB-MSCs and suggested it as a cell marker that can measure differentiation state of hUCB-MSCs for the first time.

· Issue information | Biochem Biophys Res Commun. 2009 Apr 17;381(4):676-81.
· Co-author | Jin HJ, Park SK, Oh W, Yang YS, Kim SW, Choi SJ.
Stem Cells | 2009-04-01
Overexpression of CXC chemokine receptors is required for the superior glioma- tracking property of umbilical cord blood-derived mesenchymal stem cells.
This study suggests that glioma cells secretes IL-8 and GRO-alpha and hUCB-MSCs expressing receptors to them, CXCR-1, 2, are effective in glioma therapy.

· Issue information | Stem Cells Dev. 2009 Apr;18(3):511-9.
· Co-author | Kim DS, Kim JH, Lee JK, Choi SJ, Kim JS, Jeun SS, Oh W, Yang YS, Chang JW.
Stem Cells | 2008-12-01
Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma.
This study proves that hUCB-MSCs play a role as a useful delivery vehicle in gene transfer therapy against intracranial glioma.

· Issue information | Cancer Res. 2008 Dec 1;68(23):9614-23.
· Co-author | Kim SM, Lim JY, Park SI, Jeong CH, Oh JH, Jeong M, Oh W, Park SH, Sung YC, Jeun SS.
Stem Cells | 2008-08-01
Brain-derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt-dependent signaling pathways.
This study are results confirming signaling in neuronal differentiation of hUCB-MSCs by BDNF.

· Issue information | J Neurosci Res. 2008 Aug 1;86(10):2168-78.
· Co-author | Lim JY, Park SI, Oh JH, Kim SM, Jeong CH, Jun JA, Lee KS, Oh W, Lee JK, Jeun SS.
Others | 2008-07-01
Impact of myocardial infarct proteins and oscillating pressure on the differentiation of mesenchymal stem cells: effect of acute myocardial infarction on stem cell differentiation.
This study proves experimentally that differentiation ability of hUCB-MSC to cardiomyocyte and its therapeutic effect in acute myocardial infarction model.

· Issue information | Stem Cells. 2008 Jul;26(7):1901-12.
· Co-author | Chang SA, Lee EJ, Kang HJ, Zhang SY, Kim JH, Li L, Youn SW, Lee CS, Kim KH, Won JY, Sohn JW, Park KW, Cho HJ, Yang SE, Oh WI, Yang YS, Ho WK, Park YB, Kim HS.
Stem Cells | 2008-02-01
Cytotoxicity of human umbilical cord blood-derived mesenchymal stem cells against human malignant glioma cells.
This is a study confirming whether hUCB-MSCs without external cell activation show cytotoxicity to malignant glioma, using hUCB-MSCs with tropism toward brain tumor cells.

· Issue information | Childs Nerv Syst. 2008 Mar;24(3):293-302.
· Co-author | Kang SG, Jeun SS, Lim JY, Kim SM, Yang YS, Oh WI, Huh PW, Park CK.
Stem Cells | 2008-02-01
Immunological properties of umbilical cord blood-derived mesenchymal stromal cells.
Explaining immunological properties of hUCB-MSCs, this study shows that hUCB-MSCs have no antigen inducing immune response and can control immune response, so they are proper to allogenic cell therapy.

· Issue information | Cell Immunol. 2008 Feb;251(2):116-23.
· Co-author | Oh W, Kim DS, Yang YS, Lee JK.
Others | 2007-10-01
Combined therapy of human cord blood cell transplantation and basic fibroblast growth factor delivery for treatment of myocardium infarction.
This study reports that transplantation of bFGF cytokine combined with hUCB-MSCs in myocardial infarction model can enhance the therapeutic effect.

· Issue information | Eur J Heart Fail. 2007 Oct;9(10):974-85.
· Co-author | Cho SW, Kim IK, Bhang SH, Joung B, Kim YJ, Yoo KJ, Yang YS, Choi CY, Kim BS.
Stem Cells | 2007-01-01
Effect of Aging on the Pluripotential Capacity of Human Bone Marrow Derived Mesenchymal Stem Cells.
This study is a review on clinical applicability of hUCB-MSCs, comparing differentiation ability of hUCB-MSCs according to age.

· Issue information | J Korean Orthop Assoc, 42: 701-710, 2007.
· Co-author | Jin HJ, Choi SJ, Bae YK, Lee SY, Gil MO, Park CM, Wang JH, Oh WI, Yang YS, Cho IH, Kim CG, Song HR.