|
PNEUMOSTEM | 2020-01-23 Soluble PTX3 of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Attenuate Hyperoxic Lung Injury by Activating Macrophage Polarization in Neonatal Rat Model
PTX3 is a potential marker with critical paracrine effects for predicting the therapeutic potential of MSC therapy in inflammatory diseases; quality-control assessments using PTX3 may be useful for improving the therapeutic effects of UCB-MSCs.· Issue information | Stem Cells Int. 2020, article ID 1802976. https://doi.org/10.1155/2020/1802976 · Co-author | Miyeon Kim, Ji Hye Kwon, Yun Kyung Bae, Gee-Hye Kim, Soyoun Um, Jueun Ha, Soo Jin Choi, Wonil Oh, Hye Jin Jin |
|
CARTISTEM | 2020-01-14 Implantation of allogenic umbilical cord blood-derived mesenchymal stem cells improves knee osteoarthritis outcomes: Two-year follow-up
Implantation of CARTISTEM showed effective clinical outcome for treating knee osteoarthritis based on a follow-up lasting a minimum of 2 years.· Issue information | Regen Ther. 2020 Jan 14;14:32-39. doi: 10.1016/j.reth.2019.10.003. · Co-author | Jun-Seob Song, Ki-Taek Hong, Na-Min Kim, Jae-Yub Jung, Han-Soo Park, Sang Heon Lee, Yoon Joo Cho, Seok Jung Kim |
|
Stem Cells | 2020-01-11 Up-Regulation of Superoxide Dismutase 2 in 3D Spheroid Formation Promotes Therapeutic Potency of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells
The increase in SOD2 in the spheroid form of MSCs is a particularly relevant finding relative to the improvement of therapeutic potency by enhancing cell survival and suppressing the oxidative stress in osteoarthritis.· Issue information | Antioxidants 2020, 9(1), 66; https://doi.org/10.3390/antiox901066 · Co-author | Miyoung Lee, Bo Ram Song, Dong Hyun Kim, Jueun Ha, Minju Lee, Soo Jin Choi, Wonil Oh, Soyoun Um, Hye Jin Jin |
|
PNEUMOSTEM | 2019-09-27 Decorin Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Induces Macrophage Polarization via CD44 to Repair Hyperoxic Lung Injury
Decorin as a key paracrine factor, including macrophage polarization via CD44, a master immunoregulator in human UCB-MSCs.· Issue information | Int J Mol Sci. 2019 Sep 27;20(19). pii: E4815. doi: 10.3390/ijms20194815. · Co-author | Ji Hye Kwon, Miyeon Kim, Yun Kyung Bae, Gee Hye Kim, Soo Jin Choi, Wonil Oh, Soyoun Um, Hye Jin Jin |
|
CARTISTEM | 2019-08-20 Cartilage regeneration in osteoarthritic knees treated with distal femoral osteotomy and intralesional implantation of allogenic human umbilical cord blood-derived mesenchymal stem cells: A report of two cases
CARTISTEM implantation combined with DFO showed cartilage regeneration and improving clinical outcomes in two patients with valgus deformity who had lateral compartment osteoarthritis.· Issue information | Knee. 2019 Dec;26(6):1445-1450. doi: 10.1016/j.knee.2019.07.017. · Co-author | Jun-Seob Song, Ki-Taek Hong, Na-Min Kim, Jae-Yub Jung, Han-Soo Park, You Seung Chun, Seok Jung Kim |
|
PNEUMOSTEM | 2019-04-13 Safety of Intratracheal Administration of Human Umbilical Cord Blood Derived Mesenchymal Stromal Cells in Extremely Low Birth Weight Preterm Infants
Intratracheal administration of PNEUMOSTEM treatment was well tolerated and shows to be safe and feasible in extremely low birth weight preterm Infants at high risk for bronchopulmonary dysplasia.· Issue information | J Pediatr. 2019 Jul;210:209-213.e2. doi: 10.1016/j.jpeds.2019.02.029. · Co-author | So Yoon Ahn, Yun Sil Chang, Ji Hye Kim, Se In Sung, Won Soon Park |
|
CARTISTEM | 2019-04-01 Allogenic umbilical cord blood-derived mesenchymal stem cells implantation for the treatment of juvenile osteochondritis dissecans of the knee
CARTISTEM implantation showed cartilage regeneration and improving clinical outcomes in two patients with juvenile osteochondritis dissecans of the knee at one year follow-up.· Issue information | J Clin Orthop Trauma. 2019 Oct;10(Suppl 1):S20-S25. doi: 10.1016/j.jcot.2019.03.025. · Co-author | Jun-Seob Song, Ki-Taek Hong, Na-Min Kim, Jae-Yub Jung, Han-Soo Park, Yoo-Chang Kim, Asode Ananthram Shetty, Seok Jung Kim |
|
Stem Cells | 2018-10-12 Effect of growth differentiation factor-15 secreted by human umbilical cord blood- derived mesenchymal stem cells on amyloid beta levels in in vitro and in vivo models of Alzheimer's disease
This study demonstrated in an Alzheimer's disease model that secretory protein of umbilical cord blood-derived mesenchymal stem cells, GDF-15 promotes the removal of amyloid beta by improving the secretion of IDE(insulin-degrading enzyme) well-known as a representative amyloid-degrading enzyme through the regulation of microglia in the nervous system. This study is meaningful in that it further clarified that previously reported GDF-15 is effective in promoting amyloid beta removal in addition to the nerve regeneration effect as a role of multi-function.· Issue information | 2018 Oct 12;504(4):933-940. doi: 10.1016/j.bbrc.2018.09.012. Epub 2018 Sep 14. · Co-author | Dong Hyun Kim, Dahm Lee, Hoon Lim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Jong Ho Jang |
|
Stem Cells | 2018-09-05 Cobalt Chloride Enhances the Anti-Inflammatory Potency of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells through the ERK-HIF-1α-MicroRNA-146a-Mediated Signaling Pathway
MSC shows therapeutic effects through paracrine secretion or intercellular contact that regulates inflammatory or immune responses. Through the asthma mouse model, this study showed that CoCl2 enhances the anti-inflammatory activity of MSC through the ERK-HIF-1a-miRNA124a pathway, and CoCl2 has better therapeutic efficacy for inflammatory diseases of pretreated MSC.· Issue information | 2018 Sep 5;2018:4978763. doi: 10.1155/2018/4978763 · Co-author | Ji Hye Kwak, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon, Eun Su Jeon |
|
Others | 2018-08-06 Modeling and Staging of Osteoarthritis Progression Using Serial CT Imaging and Arthroscopy
This study presents an animal model of degenerative arthritis similar to humans in which the meniscal release method can be used to induce degenerative arthritis in sheep and then, the degree of cartilage damage can be checked with CT images and arthroscopy without the sacrifice of the object to determine when to administer the therapeutic agent.· Issue information | Cartilage. 2018 Aug 6:1947603518789997. doi: 10.1177/1947603518789997 · Co-author | Candace Flynn, Mark Hurtig, Emma Lamoure, Erin Cummins, Valeria Roati, Mark Lowerison, Sang Young Jeong, Wonil Oh, Alex Zur Linden |